The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein‐protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review (...) will focus on the multifaceted nature of protein‐protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation. (shrink)

The McKinsey Problem concerns a puzzling implication of the doctrines of Content Externalism and Privileged Access. I provide a categorization of possible solutions to the problem. Then I discuss Crispin Wright’s work on the problem. I argue that Wright has misconceived the status of his own proferred solution to the problem.

Michael Williams and Crispin Wright have claimed that we are epistemically justified in believing hinge propositions, such as there is an external world. In a recent paper Allan Hazlett puts forward an argument that purports to elucidate the source of such justification. This paper reconstructs Hazlett's argument and offers a criticism of it.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy of Music Education Review 12.2 (2004) 126-138 [Access article in PDF] Music Education for the Twenty-First Century A Philosophical View of the General Education Core Anthony J. Palmer Boston University We are all one species with one brain and neural system, yet consciousness about our existence is highly contextual. Any culturally transcendent view will still be limited to one's personal experience, analytical capabilities, and cultural shaping. Nevertheless, (...) looking beyond our narrow perspectives is essential if we are to find commonality and compatibility with all humankind.Therefore, I find it incumbent that we, as college/university professors, examine our present culture-national and global-to ascertain current conditions and what positive roles each citizen may be able to play on the larger stage of world affairs. Musician-teachers, who are the products of the curriculum, should not be exempt from the responsibilities of contributing solutions. Rather, they should produce a program that is sensitive to the larger context in which we all reside. To be sure, we have no direct control over global events. We do, however, exercise at least a modicum of control over the kind of person emerging from our courses of study.In light of the foregoing, this paper will examine (1) the present global conditions with which we are confronted, (2) responsibilities of the college/university [End Page 126] faculties toward developing students with greater awareness, (3) examination of the general education that all baccalaureate students must satisfy for the degree, (4) the education within the general education courses with a focus on the music education student, and (5) a proposal on general education. The Present Context Today we are at a juncture where no one can predict the future with any assurance of accuracy. The world in the twenty-first century has taken an unexpected turn toward greater chaos and has the potential to end life as we have known it in previous centuries. Although earlier generations experienced many changes and watershed moments, the conditions were never potentially as cataclysmic as they are today because of the explosive power of our so-called defensive weapons. In addition, fed by technology, the pace of change is extremely rapid and multiplies exponentially. Robert Wright states in this regard, Neither biological evolution nor human history is a smooth, steady process. Both pass through thresholds.... To some people, the current era has the aura of a threshold; it has that unsettling, out-of-control feeling that can portend a major shift. Technological, geopolitical, and economic change seem ominously fast, and the fabric of society seems somehow tenuous.1He goes on to say, World currency markets are rocked by the turbulent force of electronically lubricated financial speculation. Weapons of mass destruction are cultivated by rogue regimes and New Age cults. Nations seem less cohesive than before, afflicted by ethnic or religious or cultural friction. Health officials seriously discuss the prospect of a worldwide plague-the unspeakably gruesome Ebola virus, perhaps, or some microbe we don't yet know about, spread around the world by jet-propelled travelers. Even tropical storms seem to have grown more intense in recent decades, arguably a result of global warming.2The foregoing was written in 2000, well before the devastating events of September 11 and subsequent human-initiated disasters, yet it still rings true. Where are we heading? What is our future with a world torn by terror, the continual development of more destructive weapons, and a seeming lack of desire to ameliorate our differences in a peaceful manner? Add to these the inexorable advance of technology that seems to know no end. It is most likely that the world in 2050-perhaps even as early as 2025-will not be recognized by our present population, assuming that we do survive as a civilized world.Of course, the outlook is not exclusively bleak and the continued development of technology is not all on the debit side of the ledger. Advances made in [End Page 127] medicine portend the re-growing of brain cells, repair... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy of Music Education Review 12.2 (2004) 126-138 [Access article in PDF] Music Education for the Twenty-First Century A Philosophical View of the General Education Core Anthony J. Palmer Boston University We are all one species with one brain and neural system, yet consciousness about our existence is highly contextual. Any culturally transcendent view will still be limited to one's personal experience, analytical capabilities, and cultural shaping. Nevertheless, (...) looking beyond our narrow perspectives is essential if we are to find commonality and compatibility with all humankind.Therefore, I find it incumbent that we, as college/university professors, examine our present culture-national and global-to ascertain current conditions and what positive roles each citizen may be able to play on the larger stage of world affairs. Musician-teachers, who are the products of the curriculum, should not be exempt from the responsibilities of contributing solutions. Rather, they should produce a program that is sensitive to the larger context in which we all reside. To be sure, we have no direct control over global events. We do, however, exercise at least a modicum of control over the kind of person emerging from our courses of study.In light of the foregoing, this paper will examine (1) the present global conditions with which we are confronted, (2) responsibilities of the college/university [End Page 126] faculties toward developing students with greater awareness, (3) examination of the general education that all baccalaureate students must satisfy for the degree, (4) the education within the general education courses with a focus on the music education student, and (5) a proposal on general education. The Present Context Today we are at a juncture where no one can predict the future with any assurance of accuracy. The world in the twenty-first century has taken an unexpected turn toward greater chaos and has the potential to end life as we have known it in previous centuries. Although earlier generations experienced many changes and watershed moments, the conditions were never potentially as cataclysmic as they are today because of the explosive power of our so-called defensive weapons. In addition, fed by technology, the pace of change is extremely rapid and multiplies exponentially. Robert Wright states in this regard, Neither biological evolution nor human history is a smooth, steady process. Both pass through thresholds.... To some people, the current era has the aura of a threshold; it has that unsettling, out-of-control feeling that can portend a major shift. Technological, geopolitical, and economic change seem ominously fast, and the fabric of society seems somehow tenuous.1He goes on to say, World currency markets are rocked by the turbulent force of electronically lubricated financial speculation. Weapons of mass destruction are cultivated by rogue regimes and New Age cults. Nations seem less cohesive than before, afflicted by ethnic or religious or cultural friction. Health officials seriously discuss the prospect of a worldwide plague-the unspeakably gruesome Ebola virus, perhaps, or some microbe we don't yet know about, spread around the world by jet-propelled travelers. Even tropical storms seem to have grown more intense in recent decades, arguably a result of global warming.2The foregoing was written in 2000, well before the devastating events of September 11 and subsequent human-initiated disasters, yet it still rings true. Where are we heading? What is our future with a world torn by terror, the continual development of more destructive weapons, and a seeming lack of desire to ameliorate our differences in a peaceful manner? Add to these the inexorable advance of technology that seems to know no end. It is most likely that the world in 2050-perhaps even as early as 2025-will not be recognized by our present population, assuming that we do survive as a civilized world.Of course, the outlook is not exclusively bleak and the continued development of technology is not all on the debit side of the ledger. Advances made in [End Page 127] medicine portend the re-growing of brain cells, repair... (shrink)

In this paper I provide an account of the metaphysical foundations of mental illness in terms of a realism debate. I motivate the importance of such metaphysical analysis as a means of avoiding some intractable problems that beset discussion of the concept of mental illness. I apply aspects of the framework developed by Crispin Wright for realism debates in order to examine the ontological commitments to mental illness as a property that humans may exhibit and to examine the various (...) arguments that realists and anti-realists can use to defend their position on mental illness. I pay particular attention to characterising Szasz's account of mental illness as that of an anti-realist error-theory and present ways in which a realist may counter such a position. Ultimately I argue that in order to hold a realist position on mental illness one would have to adopt some form of realism towards values, such as moral realism. (shrink)

In Interplay of Things Anthony B. Pinn theorizes religion as a technology for interrogating human experiences and the boundaries between people and other things. Rather than considering religion in terms of institutions, doctrines, and creeds, Pinn shows how religion exposes the openness and porousness of all things and how they are always involved in processes of exchange and interplay. Pinn examines work by Nella Larsen and Richard Wright that illustrates an openness between things and traces how pop art (...) and readymades point to the multidirectional nature of influence. He also shows how Ron Athey's and Clifford Owens' performance art draws out inherent interconnectedness to various cultural codes in ways that reveal the symbiotic relationship between art and religion as a technology. Theorizing that antiblack racism and gender- and class-based hostility constitute efforts to close off the porous nature of certain bodies, Pinn shows how many artists have rebelled against these attempts to counter openness. His analyses offer a means with which to understand the porous, unbounded, and open nature of humans and things. (shrink)

Background Analysis of aphasic narratives can be a challenge for clinicians. Previous studies have mainly employed measures that categorized speech samples at the word level. They included quantification of the use and misuse of different word classes, presence and absence of narrative contents and errors, paraphasias, and perseverations, as well as morphological structures and errors within a narrative. In other words, a great amount of research has been conducted in the aphasiology literature focusing on micro-linguistic structures of oral narratives. Aspects (...) of macro- linguistic structures, such as the analysis of content information by a speaker, consistency of using cohesive devices to present information within a narrative, and order of presenting information necessary to form a coherent discourse, have not been extensively investigated. The current investigation proposes a clinical analytic system to target three aspects of macro-linguistic structures in narratives among speakers with aphasia. Specifically, (1) the presence of search events (i.e., the mentioning of key events that allow the listener to understand; Capilouto, Wright, &Wagovich, 2006) within a narrative, (2) the sequence of the mentioned events, and (3) the informativeness (i.e., the fulfillment of lexical items that allow the user to understand what the event is detailing) of the event contents, were focused in the proposed framework. Method Ten controls transcripts from were selected from the AphasiaBank (MacWhinney, Fromm, Forbes, & Holland, 2011). Three narrative tasks, including sequential picture description of ‘Refused Umbrella’, procedural narrative of making a ‘Peanut Butter and Jelly Sandwich’, and telling of ‘Cinderella’ story, were used to establish normative data for the basis of analysis. Specifically, the Search Events (e) and Informative Words (i) used by at least 70% of the speakers were listed for each genre. The sequential order of mentioning the Search Events, i.e., common order of events in 90% of the speakers, (s.total) was determined. Twelve speakers with aphasia (nine fluent and three non-fluent) were recruited and administered the Western Aphasia Battery and Object and Action Naming Battery. Their performance in the above three discourse tasks were orthographically transcribed and analyzed using the following measures: e.total, e.matched with norm, e.missed, e.irrlevant, e.extra, s.total, i.pb&j, i.umbr, i.cind, and i.total. Three samples were randomly chosen to be re-analyzed for inter- and intra-rater reliability. Results Results of an independent t-test suggested significant differences between the fluent and non-fluent subjects in sequential order of Search Events for all genres (s.total) and i.total, suggesting sensitivity of this framework to differentiate between the two fluency groups. Results of Pearson product-moment correlations revealed significant relation between Informative Words and WAB spontaneous speech scores, AQ, as well as OAB scores, for both aphasic groups. The mean value of coefficients for intra-rater reliability (0.992), with significant correlations on e.match, e.miss, and e.extra, was higher than that of inter-rater reliability (0.897). Discussion Based on our preliminary results, this objective framework allowed clinical evaluation of impairment in macro-linguistic structures present in aphasic discourse. Further extension should involve more subjects encompassing a wider range of severity with different types of aphasia. (shrink)

These lines, presented as they appear in the O.C.T., are among the most difficult and hotly disputed that Juvenal wrote. The poet defends his decision not to attack contemporary politicians directly: ‘expose a Tigellinus’, he says, ‘and you know what the consequences will be’. It has long been recognized that the consequences related are probably inspired by those suffered by the Christians in A.D. 64 during the reign of Nero, and so vividly described by Tacitus.

When Claudius came to power in January 41 he did not hesitate to distance himself from his predecessor's behaviour and policies, and among other measures, Suetonius reports, he abolished all Gaius' acta. The precise implications of this move are not made clear. Certainly, the extremely unpopular taxes introduced in Rome near the end of Gaius' reign were annulled, several people convicted of maiestas were set free, and the monies previously confiscated from negligent, and possibly corrupt, road commissioners were returned. But (...) if the abolition of the acta was as sweeping as Suetonius seems to imply, a number of popular and useful measures must inevitably have been abrogated at the same time, and as a matter of routine they would need to be reintroduced by Claudius. The arrangements with the client kings may well have belonged to this general category, and if we assume that this was indeed the case we shall have an explanation for a number of apparent inconsistencies in the literary sources. It should be observed that in the early part of his principate Gaius went out of his way to be a ‘constitutional’ ruler. The appointment of the client kings would have been handled so as not to seem like the arbitrary exercise of power. Certainly, when the three sons of the murdered king of Thrace, Polemo, Cotys and Rhoemetalces received new kingdoms in 38, Dio stresses that the act was legitimised by a formal senatorial decree. If client kings had generally been established by a formal and legal process their appointments could quite well have come to an end with the abolition of the acta in January 41. (shrink)

It has been claimed that the attempt to analyze know-how in terms of propositional knowledge over-intellectualizes the mind. Exploiting the methods of so-called “experimental philosophy”, we show that the charge of over-intellectualization is baseless. Contra neo-Ryleans, who analyze know-how in terms of ability, the concrete-case judgments of ordinary folk are most consistent with the view that there exists a set of correct necessary and sufficient conditions for know-how that does not invoke ability, but rather a certain sort of propositional knowledge. (...) To the extent that one’s considered judgments agree with those of the folk (or to the extent that one is unwilling to contravene widespread judgments), this constitutes a strong prima facie case against neo-Ryleanism. (shrink)

The year of Livia's birth is nowhere explicitly recorded in any ancient sources, and can be determined only by calculating back from the date given in the sources for the year of her death. Both Tacitus and Dio place that death securely in A.D. 29. Tacitus limits himself to the observation that by then she had lived into extreme old age, aetate extrema, but Dio adds the more precise and useful information that at the time of her death she had (...) lived for eighty-six years: ef ξ καì ὀγδοκουτα τη ζσασα Less usefully, Pliny the Elder states that Livia herself attributed her eighty-two years to her consumption of Pucine wine, which she drank exclusively . Whatever the merits of Pliny's health tips, his chronological information is of little service in determining when she was born. (shrink)

John Hyman has used the objective character of occlusion shapes and of relative occlusion sizes to develop a more objective approach both in the analysis of linear perspective and in the theory of depiction. To this end Hyman develops two Occlusion Principles, plus an Aperture Colour Principle (which I do not discuss), which, together with our knowledge of appearances, are supposed to tell us what a picture depicts. I argue that Hyman underestimates the crucial role of the psychological element in (...) the work that the objective occlusion shape and relative occlusion sizes are assigned to do. Two pictures may have different contents in spite of the same occlusion shapes and the same (relative) occlusion sizes. It is the operation of constancy scaling in pictorial space which frustrates Hyman’s objectivism both in the domain of linear perspective and in the domain of depiction. (shrink)

For the lack of forty-nine drachmas Socrates was unable to attend the costly epideixis of Prodicus from which he would have learnt the truth about correct use of words. From Prodicus' ὥραι Socrates could also have learnt the concepts and characteristic words associated with arete and kakia: these compete in that work for the allegiance of Heracles, parading their respective characteristics. Thanks to Professor Arthur Adkins we have had for the past decade a book which not only confronts arete and (...) kakia, but also analyses the meaning and usage of many Greek words for the evaluation of action from Homer to Aristotle. The importance of this book is generally acknowledged but it has not received the detailed discussion it deserves. Professor Adkins finds the social structure of ancient Greece inimical to the development of an adequate concept of moral responsibility. He shows, in a most interesting manner, how Greek values changed as the needs of society changed. (shrink)

Dennett's "Consciousness Explained" (1991) is an inspiring but also a highly frustrating book. The line of the argument seems to be clear, but then at second sight it fades away. It turns out that Dennett uses six of the seven strategies which I discuss in my 'The Seven Strategies of the Sophisticated Pseudo-Scientist: A Look into Freud's Rhetorical Tool Box' (J. Gen. Phil. Sci., 2001) Discussing important examples of these strategies I show why "Consciousness Explained" is such a frustrating book. (...) As the examples used do not reflect minor problems but go to the heart of the matter and concern the book's main areas of contention, it turns out that, in spite of the valuable and insightful details, Dennett's materialistic view of consciousness is supported mainly by rhetorical sleights of hand. (shrink)

Older adults prefer positive over negative information in a lab setting, compared to young adults. The extent to which OA avoid negative events or information relevant for their health and safety is not clear. We first investigated age differences in preferences for fear-enhancing vs. fear-reducing news articles during the Ebola Outbreak of 2014. We were able to collect data from 15 YA and 13 OA during this acute health event. Compared to YA, OA were more likely to read the fear-enhancing (...) article, select hand-sanitizer over lip balm, and reported greater fear of Ebola. We further investigated our research question during the COVID-19 pandemic with 164 YA and 171 OA. Participants responded to an online survey about the COVID-19 pandemic across 13 days during the initial peak of the pandemic in the United States. Both YA and OA preferred to read positive over negative news about the coronavirus, but OA were even more likely than YA to prefer the positive news article. No age differences in the fear of contraction were found, but OA engaged in more health-protective behaviors compared to YA. Although OA may not always report greater fear than YA or seek out negative information related to a health concern, they still engage in protective health behaviors. Thus, although positivity effects were observed in attention and emotional reports, OA still modified their behaviors more than YA, suggesting that positivity effects did not hamper OA ability to respond to a health crisis. (shrink)

This essay argues that Stoicism is the ancient philosophy most relevant to modern politics and civic education. Its relevance is due not to the advocacy of any specific political system or public policy but to its theory that the human good depends primarily on rationality and excellence of character rather than on material prosperity and productivity. According to Stoicism, all human beings are related to one another in virtue of our communal nature as rational animals. Reflection on the norms of (...) human nature persuaded the Stoics that we all share a common interest in living just and mutually beneficial lives. This principle, though it favors an equitable distribution of goods and services, makes rationality and integrity, rather than material prosperity, the essential values of community and the measure of normative citizenship and lawmaking. Our goal as Stoic citizens is to practice the art of what is always possible or in our power—doing our best to live mutually beneficial and well-reasoned lives—while recognizing that the external success we are naturally inclined to aim at may be frustrated because we live in a world we can never fully control. (shrink)

This book is a collection of fourteen essays on the themes of selfhood and rationality in ancient Greek philosophy. The discussion ranges over seven centuries of innovative thought, starting with Heraclitus’ injunction to listen to the cosmic logos, and concluding with Plotinus’ criticism of those who make embodiment essential to human identity. For the Greek philosophers the notion of a rational self was bound up with questions about divinity and happiness called eudaimonia, meaning a god-favoured life or a life of (...) likeness to the divine. While these questions are remote from current thought, Long also situates the book’s themes in modern discussions of the self and the self’s normative relation to other people and the world at large. Ideas and behaviour attributed to Socrates and developed by Plato are at the book’s centre. They are preceded by essays that explore general facets of the soul’s rationality. Later chapters bring in salient contributions made by Aristotle and Stoic philosophers. All but one of these pieces has been previously published in periodicals or conference volumes, but the author has revised and updated everything. The book is written in a style that makes it accessible to many kinds of reader, not only professors and graduate students but also anyone interested in the history of our identity as rational animals. (shrink)